論文 - 詳細
| RRC ID | 17697 |
|---|---|
| 著者 | Yoshioka S, Terashita T, Yoshizumi H, Shirasaka N. |
| タイトル | Inhibitory effects of whisky polyphenols on melanogenesis in mouse B16 melanoma cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Whisky exerts an inhibitory effect on melanogenesis in B16 cells, the anti-melanogenic activity being positively correlated with the aging period and anti-oxidative activity of whisky. We examined the correlation between the inhibition of melanogenesis and the concentration of each compound in various whiskies to evaluate the importance of 11 different whisky polyphenols, including ellagic acid, gallic acid and lyoniresinol, in the anti-melanogenic activity of whisky. The concentration of all the compounds was positively correlated with the anti-melanogenic activity of whisky. Ellagic acid, gallic acid and lyoniresinol were the predominant polyphenols in the whiskies measured by HPLC. These three compounds also significantly inhibited the melanogenesis and tyrosinase activity in B16 cells. Ellagic acid, gallic acid and lyoniresinol were confirmed as the major participants in the anti-melanogenic activity of whisky. |
| 巻・号 | 75(12) |
| ページ | 2278-82 |
| 公開日 | 2011-1-1 |
| DOI | 10.1271/bbb.100514 |
| PII | JST.JSTAGE/bbb/100514 |
| PMID | 22146709 |
| MeSH | Alcoholic Beverages* Animals Antioxidants / pharmacology* Cell Line, Tumor Melanins / biosynthesis* Melanoma, Experimental / pathology* Mice Monophenol Monooxygenase / metabolism Polyphenols / pharmacology* |
| IF | 1.516 |
| 引用数 | 8 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |