| RRC ID |
17697
|
| 著者 |
Yoshioka S, Terashita T, Yoshizumi H, Shirasaka N.
|
| タイトル |
Inhibitory effects of whisky polyphenols on melanogenesis in mouse B16 melanoma cells.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Whisky exerts an inhibitory effect on melanogenesis in B16 cells, the anti-melanogenic activity being positively correlated with the aging period and anti-oxidative activity of whisky. We examined the correlation between the inhibition of melanogenesis and the concentration of each compound in various whiskies to evaluate the importance of 11 different whisky polyphenols, including ellagic acid, gallic acid and lyoniresinol, in the anti-melanogenic activity of whisky. The concentration of all the compounds was positively correlated with the anti-melanogenic activity of whisky. Ellagic acid, gallic acid and lyoniresinol were the predominant polyphenols in the whiskies measured by HPLC. These three compounds also significantly inhibited the melanogenesis and tyrosinase activity in B16 cells. Ellagic acid, gallic acid and lyoniresinol were confirmed as the major participants in the anti-melanogenic activity of whisky.
|
| 巻・号 |
75(12)
|
| ページ |
2278-82
|
| 公開日 |
2011-1-1
|
| DOI |
10.1271/bbb.100514
|
| PII |
JST.JSTAGE/bbb/100514
|
| PMID |
22146709
|
| MeSH |
Alcoholic Beverages*
Animals
Antioxidants / pharmacology*
Cell Line, Tumor
Melanins / biosynthesis*
Melanoma, Experimental / pathology*
Mice
Monophenol Monooxygenase / metabolism
Polyphenols / pharmacology*
|
| IF |
1.516
|
| 引用数 |
8
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |
