論文 - 詳細
| RRC ID | 177 |
|---|---|
| 著者 | Murakami T, Kobayashi E. |
| タイトル | Color-engineered rats and luminescent LacZ imaging: a new platform to visualize biological processes. |
| ジャーナル | J Biomed Opt |
| Abstract |
The rat represents an excellent mammalian model for broadening medical knowledge, and a wealth of information on its physiology has been obtained from its use as an experimental organism. Furthermore, its ample body size allows various surgical manipulations that cannot be performed on a mouse. Many rat models mimic human diseases and have therefore been used in a variety of biomedical studies, including physiology, pharmacology, and transplantation. In an effort to create specifically designed rats for new biomedical research and the field of regenerative medicine, we develop an engineered rat system on the basis of transgenic technology and succeed in establishing unique rats that possess genetically encoded color probes: green fluorescent protein (GFP), DsRed2 (red liver), Cre/LoxP (red to green), and LacZ (blue and luminescence). In this work, we highlight their characteristics and describe recent applications for tissue engineering and regeneration. Coupled with recent progress in modern imaging systems, these transgenic rats are providing powerful tools for the elucidation of many cellular processes in biomedical science, and may lead to innovative medical treatments. |
| 巻・号 | 10(4) |
| ページ | 41204 |
| 公開日 | 2005-1-1 |
| DOI | 10.1117/1.2007947 |
| PMID | 16178628 |
| MeSH | Animals Animals, Genetically Modified / anatomy & histology* Animals, Genetically Modified / metabolism* Color Genetic Enhancement / methods Image Enhancement / methods* Luminescent Proteins / genetics Luminescent Proteins / metabolism* Microscopy, Fluorescence / methods* Models, Animal* Rats beta-Galactosidase / genetics beta-Galactosidase / metabolism* |
| IF | 2.785 |
| 引用数 | 22 |
| WOS 分野 | OPTICS RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOCHEMICAL RESEARCH METHODS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | |