Reference - Detail
| RRC ID | 1790 |
|---|---|
| Author | Korayem AM, Fabbri M, Takahashi K, Scherfer C, Lindgren M, Schmidt O, Ueda R, Dushay MS, Theopold U. |
| Title | A Drosophila salivary gland mucin is also expressed in immune tissues: evidence for a function in coagulation and the entrapment of bacteria. |
| Journal | Insect Biochem Mol Biol |
| Abstract |
Our studies on the developmental regulation of glycosylation in Drosophila melanogaster led us to identify and characterize gp150, an ecdysone-regulated mucin that is found in hemocytes, the gut (peritrophic membrane) and in the salivary glands. We are particularly interested in mucin immune functions and found that gp150 is released from larval hemocytes, becomes part of the clot and participates in the entrapment of bacteria. By RT-PCR and RNAi experiments, we identified gp150 as the previously described I71-7, an ecdysone-induced salivary glue protein. We discuss the evolutionary and biochemical implications of the dual use of salivary proteins for immune functions in insects. Further molecular characterization of such shared proteins may enable a better understanding of the properties of proteins involved in containment and elimination of microbes, as well as hemostasis and wound repair. |
| Volume | 34(12) |
| Pages | 1297-304 |
| Published | 2004-12-1 |
| DOI | 10.1016/j.ibmb.2004.09.001 |
| PII | S0965-1748(04)00155-9 |
| PMID | 15544943 |
| MeSH | Amino Acid Sequence Animals Bacteria / immunology Drosophila Proteins Drosophila melanogaster / genetics Drosophila melanogaster / immunology* Drosophila melanogaster / microbiology Ecdysone / physiology Gene Expression Regulation, Developmental Glycosylation Hemocytes Hemolymph Immunity, Innate Insect Proteins / biosynthesis* Insect Proteins / physiology* Larva / metabolism Membrane Glycoproteins / biosynthesis* Membrane Glycoproteins / physiology* Molecular Sequence Data Mucins / biosynthesis* Mucins / physiology* Reverse Transcriptase Polymerase Chain Reaction Salivary Glands / metabolism |
| IF | 3.827 |
| Times Cited | 46 |
| WOS Category | ENTOMOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 7604R-1 7604R-2 |