RRC ID 18086
Author Li LX, Atif SM, Schmiel SE, Lee SJ, McSorley SJ.
Title Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.
Journal J Immunol
Abstract Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPα-deficient (Sirpα⁻/⁻) mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpα⁻/⁻ mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver. Moreover, Salmonella-specific Ab production and Ag-specific CD4 T cells were reduced in Sirpα⁻/⁻ mice compared with wild-type controls. To further characterize the potential mechanism underlying SIRPα-dependent Ag-specific CD4 T cell priming, we demonstrate that lack of SIRPα expression on dendritic cells results in less efficient Ag processing and presentation in vitro. Collectively, these findings demonstrate an indispensable role of SIRPα for protective immunity to Salmonella infection.
Volume 189(5)
Pages 2537-44
Published 2012-9-1
DOI 10.4049/jimmunol.1200429
PII jimmunol.1200429
PMID 22851710
PMC PMC3424330
MeSH Animals Chlamydia Infections / genetics Chlamydia Infections / immunology Chlamydia Infections / pathology Chlamydia muridarum / immunology Genetic Predisposition to Disease* Mice Mice, 129 Strain Mice, Congenic Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Receptors, Immunologic / deficiency* Receptors, Immunologic / genetics Salmonella Infections / genetics Salmonella Infections / immunology* Salmonella Infections / pathology Salmonella typhimurium / immunology Up-Regulation / genetics Up-Regulation / immunology*
IF 4.886
Times Cited 5
Mice RBRC01544