論文 - 詳細
| RRC ID | 18088 |
|---|---|
| 著者 | Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A. |
| タイトル | Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. |
| ジャーナル | J Exp Med |
| Abstract |
When a cell undergoes apoptosis, phosphatidylserine (PS) is exposed on the outer leaflet of the plasma membrane. PS acts as an "eat-me" signal to direct phagocytes expressing PS receptors to engulf the apoptotic cell. We recently reported that the immunoreceptor CD300a, which is expressed on myeloid cells, is a PS receptor. We show that CD300a does not facilitate macrophage phagocytosis of apoptotic cells. Instead, CD300a delivers an inhibitory signal in mast cells to suppress production of LPS-induced inflammatory cytokines and chemokines. After cecal ligation and puncture (CLP), when a large number of cells undergo apoptosis in the peritoneal cavity, CD300a-deficient peritoneal mast cells produced more chemoattractant and recruited more neutrophils than did wild-type (WT) mast cells. As a result, CD300a-deficient mice showed increased neutrophil recruitment and improved bacterial clearance in the peritoneal cavity, and survived longer than WT mice. Antibody blockade of CD300a-PS interactions improved bacterial clearance and extended survival of WT mice subjected to CLP. These results indicated that CD300a is a nonphagocytic PS receptor that regulates mast cell inflammatory responses to microbial infections. |
| 巻・号 | 209(8) |
| ページ | 1493-503 |
| 公開日 | 2012-7-30 |
| DOI | 10.1084/jem.20120096 |
| PII | jem.20120096 |
| PMID | 22826299 |
| PMC | PMC3409498 |
| MeSH | Animals Apoptosis / immunology* Chemokines / immunology Chemokines / metabolism Cytokines / immunology Cytokines / metabolism Humans Inflammation / immunology* Inflammation / metabolism Inflammation / pathology Macrophages / immunology Macrophages / metabolism Mast Cells / immunology* Mast Cells / metabolism Mast Cells / pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL NIH 3T3 Cells Neutrophil Infiltration / immunology Neutrophils / immunology Neutrophils / metabolism Phagocytosis / immunology Phosphatidylserines / immunology Phosphatidylserines / metabolism Receptors, Immunologic / immunology* Receptors, Immunologic / metabolism* |
| IF | 11.743 |
| 引用数 | 51 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01888 |