論文 - 詳細
| RRC ID | 18114 |
|---|---|
| 著者 | Akashi M, Higashi T, Masuda S, Komori T, Furuse M. |
| タイトル | A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Cell-cell junctions play crucial roles in the organization and function of epithelial and endothelial cellular sheets. Here, we have identified the protein product for KIAA1462 gene, whose single nucleotide polymorphisms (SNPs) have recently reported to be associated with coronary artery disease, as a novel component of cell-cell junctions. We propose the name of KIAA1462 protein junctional protein associated with coronary artery disease (JCAD). JCAD is a ∼145 kDa protein without any known domains but contains a proline-rich region. Immunolocalization studies revealed that JCAD is specifically localized at cell-cell junctions in endothelial cells but not in epithelial cells. The accumulation of JCAD at cell-cell junctions in cultured endothelial cells was impaired by RNAi-mediated suppression of VE-cadherin expression. In cell adhesion-deficient mouse L fibroblasts, JCAD was recruited to cell-cell contacts when cadherin-mediated cell-cell adhesion was induced. These results indicate that JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. This study also suggests the implication of endothelial cell-cell adhesion in coronary artery disease. |
| 巻・号 | 413(2) |
| ページ | 224-9 |
| 公開日 | 2011-9-23 |
| DOI | 10.1016/j.bbrc.2011.08.073 |
| PII | S0006-291X(11)01473-2 |
| PMID | 21884682 |
| MeSH | Animals Antigens, CD / metabolism Cadherins / metabolism Cell Adhesion Molecules / genetics Cell Adhesion Molecules / metabolism* Cell Line Coronary Artery Disease / genetics Coronary Artery Disease / metabolism* Dogs Endothelium, Vascular / metabolism* Humans Intercellular Junctions / metabolism* Mice Protein Structure, Tertiary RNA, Small Interfering / genetics |
| IF | 2.985 |
| 引用数 | 20 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | UV♀2(RCB1994) |