RRC ID 18122
Author Fujii T, Ikeda K, Saito M.
Title Inhibitory effect of rose hip (Rosa canina L.) on melanogenesis in mouse melanoma cells and on pigmentation in brown guinea pigs.
Journal Biosci. Biotechnol. Biochem.
Abstract The compounds present in rose hips exerting an inhibitory action against melanogenesis in B16 mouse melanoma cells were investigated by dividing an aqueous extract of rose hips (RE) into four fractions. The 50% ethanol eluate from a DIAION HP-20 column significantly reduced the production of melanin and was mainly composed of procyanidin glycosides. We also found that this 50% ethanol eluate reduced the intracellular tyrosinase activity and also had a direct inhibitory effect on tyrosinase obtained as a protein mixture from the melanoma cell lysate. We also investigated the effect of orally administering RE on skin pigmentation in brown guinea pigs, and found that the pigmentation was inhibited together with the tyrosinase activity in the skin. These data collectively suggest that proanthocyanidins from RE inhibited melanogenesis in mouse melanoma cells and guinea pig skin, and could be useful as a skin-whitening agent when taken orally.
Volume 75(3)
Pages 489-95
Published 2011
DOI 10.1271/bbb.100702
PII JST.JSTAGE/bbb/100702
PMID 21389613
MeSH Administration, Oral Animals Arbutin / pharmacology Cell Line, Tumor Cell Survival / drug effects Chromatography, High Pressure Liquid Ethanol / chemistry Female Glycosides / pharmacology Glycosides / therapeutic use Guinea Pigs Melanins / antagonists & inhibitors* Melanins / biosynthesis Melanoma, Experimental / drug therapy* Melanoma, Experimental / physiopathology Mice Monophenol Monooxygenase / antagonists & inhibitors* Monophenol Monooxygenase / metabolism Plant Extracts / administration & dosage* Plant Extracts / chemistry Plant Extracts / therapeutic use Proanthocyanidins / pharmacology Proanthocyanidins / therapeutic use Rosa / chemistry Rosa / metabolism Skin / drug effects Skin / radiation effects Skin Neoplasms / drug therapy* Skin Neoplasms / physiopathology Skin Pigmentation / drug effects Skin Pigmentation / radiation effects Ultraviolet Rays / adverse effects
IF 1.297
Times Cited 7
Human and Animal Cells B16 melanoma (RCB1283)