論文 - 詳細
| RRC ID | 18142 |
|---|---|
| 著者 | Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX. |
| タイトル | Neurite outgrowth of PC12 cells on diX (parylene) family materials. |
| ジャーナル | Biotechnol Prog |
| Abstract |
We investigated neuronal cell differentiation, particularly neurite outgrowth, on the surface of diX H and diX AM using an in vitro examination of a neuron-like rat pheochromocytoma cell line, PC12. diX H and diX AM are in the parylene family of diX C (or Parylene-C), which is widely used as a novel coating material to insulate neural electrodes, and they have been recently commercialized; diX H and diX AM offer different features of biocompatibility. Previously, we found that these new parylene materials have high cell adhesiveness to neuronal cells whereas the adhesiveness of diX C is extremely low. However, their cell differentiation remains unknown although neuronal cell differentiation plays a crucial role in their development and regeneration. This study showed that almost all PC12 cells adhering to the surface of diX AM and diX H were differentiated, but the neurite outgrowth was significantly larger on diX H than that on diX AM and a conventional polystyrene culture dish. The result suggests that diX H may be advantageous as a biocompatible coating material for a scaffold, which can be used on virtually any substrate to get various configurations in neural devices. |
| 巻・号 | 28(2) |
| ページ | 587-90 |
| 公開日 | 2012-1-1 |
| DOI | 10.1002/btpr.739 |
| PMID | 22052685 |
| MeSH | Animals Cell Differentiation / drug effects* Cell Proliferation / drug effects Neurites / drug effects* Neurons / cytology* Neurons / drug effects PC12 Cells Polymers / pharmacology* Rats Xylenes / pharmacology* |
| IF | 2.334 |
| 引用数 | 5 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |