論文 - 詳細
| RRC ID | 18155 |
|---|---|
| 著者 | Habe H, Sato S, Fukuoka T, Kitamoto D, Sakaki K. |
| タイトル | Effect of glyceric acid calcium salt on the viability of ethanol-dosed gastric cells. |
| ジャーナル | J Oleo Sci |
| Abstract |
D-Glyceric acid (D-GA) calcium has been reported to accelerate ethanol oxidation in vivo in rats (Eriksson et al., Metabolism, 56, 895-898 (2007)). However, no other reports have shown that D-GA can reduce the harmful effects of ethanol. In this study, the effects of D-, L-, and DL-GA calcium on ethanol-dosed gastric cell viability were investigated using human gastric carcinoma cells (Kato III) and normal rat gastric mucosa cells (RGM1). Addition of 2% and 3 % ethanol to Kato III and RGM1 cells, respectively, decreased their cell viability by approximately 20-50 % after 24 or 72 h of cultivation. In 2 % ethanol-dosed Kato III cells cultivated for 24 h, addition of 0.002-20 µg/mL D- and L-GA calcium did not affect cell viability. Similarly, addition of less than 20 µg/mL DL-GA calcium did not affect cell viability. However, when 20 µg/mL DL-GA calcium was added, cell viability increased by 35.7 % after 72 h of incubation, compared to the viability of control cells without ethanol or GA. Addition of 20 µg/mL DL-GA calcium to 3 % ethanol-dosed RGM1 cells cultivated for 24 or 72 h also increased cell viability up to those observed in control cells. These results suggest that a racemic mixture of GA may have the strongest effect on enhancing the viability of ethanol-exposed cells. |
| 巻・号 | 60(11) |
| ページ | 585-90 |
| 公開日 | 2011-1-1 |
| DOI | 10.5650/jos.60.585 |
| PII | JST.JSTAGE/jos/60.585 |
| PMID | 22027025 |
| MeSH | Animals Calcium / chemistry Calcium / pharmacology Cell Survival / drug effects Dose-Response Relationship, Drug Ethanol / toxicity* Gastric Mucosa / drug effects* Gastric Mucosa / metabolism Gastric Mucosa / pathology Glyceric Acids / chemistry Glyceric Acids / pharmacology* Humans Rats Salts / chemistry Salts / pharmacology Time Factors |
| IF | 1.304 |
| 引用数 | 5 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RGM1(RCB0876) |