論文 - 詳細
| RRC ID | 18161 |
|---|---|
| 著者 | Odkhuu E, Koide N, Haque A, Tsolmongyn B, Naiki Y, Hashimoto S, Komatsu T, Yoshida T, Yokochi T. |
| タイトル | Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ). |
| ジャーナル | Immunol Lett |
| Abstract |
The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. RANKL led to the formation of osteoclasts identified as tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells in the culture of RAW 264.7 cells. However, PQQ inhibited the appearance of osteoclasts and prevented the decrease of F4/80 macrophage maturation marker on RANKL-stimulated cells, suggesting a preventive action of PQQ on RANKL-induced osteoclast differentiation. PQQ inhibited the activation of nuclear factor of activated T cells (NFATc1), a key transcription factor of osteoclastogenesis, in RANKL-stimulated cells. On the other hand, PQQ did not inhibit the signaling pathway from RANK/RANKL binding to NFATc1 activation, including NF-κB and mitogen-activated protein kinases (MAPKs). PQQ augmented the expression of type I interferon receptor (IFNAR) and enhanced the IFN-β-mediated janus kinase (JAK1) and signal transducer and activator of transcription (STAT1) expression. Moreover, PQQ reduced the expression level of c-Fos leading to the activation of NFATc1. Taken together, PQQ was suggested to prevent RANKL-induced osteoclast formation via the inactivation of NFATc1 by reduced c-Fos expression. The reduced c-Fos expression might be mediated by the enhanced IFN-β signaling due to augmented IFNAR expression. |
| 巻・号 | 142(1-2) |
| ページ | 34-40 |
| 公開日 | 2012-2-29 |
| DOI | 10.1016/j.imlet.2011.12.001 |
| PII | S0165-2478(11)00259-8 |
| PMID | 22193059 |
| MeSH | Animals Cell Differentiation / drug effects* Cell Line Interferon-beta / metabolism Macrophages / cytology Macrophages / drug effects* Macrophages / metabolism Mice NFATC Transcription Factors / antagonists & inhibitors* NFATC Transcription Factors / metabolism Osteoclasts / cytology* Osteoclasts / drug effects* Osteoclasts / metabolism PQQ Cofactor / pharmacology* Proto-Oncogene Proteins c-fos / metabolism RANK Ligand / metabolism RANK Ligand / pharmacology* Receptor Activator of Nuclear Factor-kappa B / metabolism Receptor, Interferon alpha-beta / metabolism Signal Transduction |
| IF | 3.276 |
| 引用数 | 10 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
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| 最多言及媒体 | Blogs |
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| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |