RRC ID 18183
Author Yang EJ, Lee JS, Yun CY, Ryang YS, Kim JB, Kim IS.
Title Suppression of ovalbumin-induced airway inflammatory responses in a mouse model of asthma by Mimosa pudica extract.
Journal Phytother Res
Abstract Asthma is an inflammatory airway disease. The pathogenic mechanisms of asthma include the infiltration of leukocytes and release of cytokines. Mimosa pudica (Mp) has been used traditionally for the treatment of insomnia, diarrhea and inflammatory diseases. Although Mp extract has various therapeutic properties, the effect of this extract on asthma has not yet been reported. This study investigated the suppressive effects of Mp extract on asthmatic responses both in vitro and in vivo. Mp extract was acquired from dried and powdered whole plants of M. pudica using 80% ethanol. BALB/c mice were used for the mouse model of asthma induced by ovalbumin. Mp extract significantly inhibited the HMC-1 cell migration induced by stem cell factor and blocked the release of monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) in EoL-1 cells. Leukocytosis, eosinophilia and mucus hypersecretion in asthmatic lung were significantly suppressed by Mp extract. The release of ovalbumin-specific IgE in bronchoalveolar lavage fluid and serum was also decreased. Mp extract treatment resulted in no liver cytotoxicity. The Mp extract has inhibitory properties on asthma and may be used as a potent therapeutic agent for allergic lung inflammation.
Volume 25(1)
Pages 59-66
Published 2011-1
DOI 10.1002/ptr.3220
PMID 20623591
MeSH Animals Anti-Asthmatic Agents / isolation & purification Anti-Asthmatic Agents / therapeutic use* Anti-Inflammatory Agents / isolation & purification Anti-Inflammatory Agents / therapeutic use* Asthma / drug therapy* Cell Line Cell Movement / drug effects Chemokine CCL2 / metabolism Disease Models, Animal Female Humans Interleukin-6 / metabolism Lung / drug effects Lung / metabolism Lung / pathology Mice Mice, Inbred BALB C Mimosa / chemistry* Ovalbumin / immunology Phytotherapy* Plant Extracts / isolation & purification Plant Extracts / therapeutic use* Stem Cell Factor / pharmacology
IF 3.766
Times Cited 12
WOS Category PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
Resource
Human and Animal Cells EoL-1 cell (RCB0641)