| RRC ID |
18212
|
| 著者 |
Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H.
|
| タイトル |
Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice.
|
| ジャーナル |
J Physiol Sci
|
| Abstract |
It remains unclear whether immune response to viral infection is inhibited by severe exercise. We determined whether exhaustive exercise inhibits interferon (IFN)-β and tumor necrosis factor (TNF)-α production after injection of synthetic double-stranded (ds) RNAs, a polyriboinosinic polyribocytidylic acid (poly I:C), as viral infection model. Male C3H/HeN mice, which were divided into exhaustive-exercised and non-exercised groups, were injected with poly I:C (5 mg/kg). Although TNF-α in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-β was no different in both groups. In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-α, but not IFN-β, production in macrophages. These results suggest that anti-virus cytokine IFN-β in response to poly I:C might be maintained despite severe stressful exercise.
|
| 巻・号 |
62(1)
|
| ページ |
59-62
|
| 公開日 |
2012-1-1
|
| DOI |
10.1007/s12576-011-0177-4
|
| PMID |
21968540
|
| MeSH |
Animals
Dopamine / pharmacology
Epinephrine / pharmacology
Interferon-beta / biosynthesis*
Macrophages / drug effects
Male
Mice
Mice, Inbred C3H
Norepinephrine / pharmacology
Physical Exertion / physiology*
Poly I-C / pharmacology*
Stress, Physiological / physiology*
Tumor Necrosis Factor-alpha / biosynthesis*
|
| IF |
2.804
|
| 引用数 |
1
|
|
WOS 分野
|
PHYSIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
