論文 - 詳細
| RRC ID | 18241 |
|---|---|
| 著者 | Yoon HE, Kim KS, Kim IY. |
| タイトル | 14-3-3 η inhibits chondrogenic differentiation of ATDC5 cell. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
It was previously shown that 14-3-3 η is overexpressed in the synovial fluid of patients with joint inflammation, which is often associated with growth failure. In this study, we investigated the role of 14-3-3 η in chondrogenesis using ATDC5 cells. Upon treatment with TNF-α, cells overexpressed 14-3-3 η with inhibition of chondrogenesis. Chondrogenesis was also inhibited by overexpression of 14-3-3 η without TNF-α treatment, whereas silencing of 14-3-3 η promoted chondrogenic differentiation. Further, G1 phase arrest was inhibited by overexpression of 14-3-3 η. In summary, we suggest that 14-3-3 η plays a regulatory role in chondrogenic differentiation. |
| 巻・号 | 406(1) |
| ページ | 59-63 |
| 公開日 | 2011-3-4 |
| DOI | 10.1016/j.bbrc.2011.01.107 |
| PII | S0006-291X(11)00159-8 |
| PMID | 21291861 |
| MeSH | 14-3-3 Proteins / genetics 14-3-3 Proteins / physiology* Animals Cell Differentiation* / drug effects Cell Differentiation* / genetics Cell Line, Tumor Chondrocytes / cytology Chondrocytes / metabolism Chondrocytes / physiology* Chondrogenesis* / drug effects Chondrogenesis* / genetics G1 Phase / drug effects Insulin / pharmacology Mice RNA, Small Interfering / genetics Tumor Necrosis Factor-alpha / pharmacology Tumor Necrosis Factor-alpha / physiology |
| IF | 2.985 |
| 引用数 | 2 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |