RRC ID 18242
Author Kitajima H, Komizu Y, Ueoka R.
Title Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis.
Journal Bioorg. Med. Chem. Lett.
Abstract Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.
Volume 22(4)
Pages 1784-7
Published 2012-2-15
DOI 10.1016/j.bmcl.2011.12.031
PII S0960-894X(11)01703-3
PMID 22260774
MeSH Apoptosis / drug effects* Cell Line, Tumor Cell Movement / drug effects Dimyristoylphosphatidylcholine / chemistry* Dimyristoylphosphatidylcholine / pharmacology Flow Cytometry Humans Inhibitory Concentration 50 Liposomes / chemistry* Liposomes / pharmacology* Molecular Structure Neoplasm Invasiveness Osteosarcoma / drug therapy Polyethylene Glycols / chemistry* Polyethylene Glycols / pharmacology
IF 2.442
Times Cited 2
Human and Animal Cells MG6 (RCB2403)