論文 - 詳細
| RRC ID | 18242 |
|---|---|
| 著者 | Kitajima H, Komizu Y, Ueoka R. |
| タイトル | Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively. |
| 巻・号 | 22(4) |
| ページ | 1784-7 |
| 公開日 | 2012-2-15 |
| DOI | 10.1016/j.bmcl.2011.12.031 |
| PII | S0960-894X(11)01703-3 |
| PMID | 22260774 |
| MeSH | Apoptosis / drug effects* Cell Line, Tumor Cell Movement / drug effects Dimyristoylphosphatidylcholine / chemistry* Dimyristoylphosphatidylcholine / pharmacology Flow Cytometry Humans Inhibitory Concentration 50 Liposomes / chemistry* Liposomes / pharmacology* Molecular Structure Neoplasm Invasiveness Osteosarcoma / drug therapy Polyethylene Glycols / chemistry* Polyethylene Glycols / pharmacology |
| IF | 2.572 |
| 引用数 | 2 |
| WOS 分野 | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC |
| リソース情報 | |
| ヒト・動物細胞 | MG6(RCB2403) |