論文 - 詳細
| RRC ID | 1830 |
|---|---|
| 著者 | Hunter WN. |
| タイトル | The non-mevalonate pathway of isoprenoid precursor biosynthesis. |
| ジャーナル | J Biol Chem |
| Abstract |
The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria. The pathway relies on eight enzymes exploiting different cofactors and metal ions. Structural and mechanistic data now exist for most components of the pathway though there remain some gaps in our knowledge. The individual enzymes represent new, validated targets for broad spectrum antimicrobial drug and herbicide development. Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest. |
| 巻・号 | 282(30) |
| ページ | 21573-7 |
| 公開日 | 2007-7-27 |
| DOI | 10.1074/jbc.R700005200 |
| PII | S0021-9258(20)78106-8 |
| PMID | 17442674 |
| MeSH | Aldose-Ketose Isomerases / metabolism Animals Apicomplexa / metabolism Bacteria / metabolism Carbon-Carbon Double Bond Isomerases / metabolism Hemiterpenes Mevalonic Acid / metabolism Multienzyme Complexes / metabolism Nucleotidyltransferases / metabolism Oxidoreductases / metabolism Phosphotransferases (Alcohol Group Acceptor) / metabolism Plants / metabolism Terpenes / metabolism* Transferases / metabolism |
| IF | 4.238 |
| 引用数 | 211 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 情報 | E.coli |