| RRC ID |
184
|
| 著者 |
Otani H, Togashi H, Jesmin S, Sakuma I, Yamaguchi T, Matsumoto M, Kakehata H, Yoshioka M.
|
| タイトル |
Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus.
|
| ジャーナル |
Eur J Pharmacol
|
| Abstract |
We examined the effect of a free radical scavenger edaravone on ischemia/reperfusion-induced impairment of long-term potentiation in the perforant path-dentate gyrus synapses of the rat hippocampus, as a measure of functional outcome 4 days after transient global ischemia (2-vessel occlusion, 10 min). Edaravone (3 and 10 mg/kg, i.v.) immediately after reperfusion (Day 0) alleviated ischemia-induced impairment of long-term potentiation in a dose-related manner, whereas treatment on Day 1 or 4 after reperfusion failed to rescue the impaired long-term potentiation. Edaravone administration on Day 0 also prevented the post-ischemic increase in hydroxyl radical formation and the expression of vascular endothelial growth factor, basic fibroblast growth factor and neuronal and inducible nitric oxide synthases of the hippocampus. Thus, edaravone protected the rat hippocampus from ischemia-induced long-term potentiation impairment with a therapeutic time window, suggesting that free radical formation after ischemia/reperfusion is a pivotal trigger of neurofunctional complications after global ischemic stroke.
|
| 巻・号 |
512(2-3)
|
| ページ |
129-37
|
| 公開日 |
2005-4-11
|
| DOI |
10.1016/j.ejphar.2005.01.050
|
| PII |
S0014-2999(05)00164-0
|
| PMID |
15840397
|
| MeSH |
Animals
Antipyrine / analogs & derivatives*
Antipyrine / pharmacology*
Blotting, Western
Brain Ischemia / physiopathology*
Edaravone
Fibroblast Growth Factor 2 / analysis
Fluorescent Antibody Technique
Free Radical Scavengers / pharmacology*
Hippocampus / drug effects*
Hippocampus / metabolism
Hippocampus / physiopathology
Hydroxyl Radical / metabolism
Long-Term Potentiation / drug effects*
Male
Microscopy, Confocal
Nitric Oxide Synthase / biosynthesis
Perforant Pathway / drug effects
Perforant Pathway / physiopathology
Rats
Rats, Wistar
Time Factors
Vascular Endothelial Growth Factor A / analysis
|
| IF |
3.263
|
| 引用数 |
32
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ラット |
|
