論文 - 詳細
| RRC ID | 18572 |
|---|---|
| 著者 | Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A. |
| タイトル | Effects of vibration on differentiation of cultured PC12 cells. |
| ジャーナル | Biotechnol Bioeng |
| Abstract |
Different types of physiological-mechanical stress, such as shear stress in vascular endothelial cells or hydrostatic pressure in chondrocytes are well known as regulators of cell function. In this study, the effects of vibration, a type of non-physiological mechanical stimulation, on differentiation of rat pheochromocytoma (PC12) cells are reported. A nano-vibration system was designed to produce nanometer-scale vibration. The frequency and amplitude of the nano-vibrations were monitored by a capacitance displacement sensor connected to an oscilloscope. When PC12 cells exposed to nerve growth factor were subjected to vibration at 10 kHz, differentiation and elongation of their neurites were promoted earlier in the culture. Vibration promoted differentiation of PC12 cells. This approach could therefore also be promising for determining of the effects of the physical environment on cell differentiation. |
| 巻・号 | 108(3) |
| ページ | 592-9 |
| 公開日 | 2011-3-1 |
| DOI | 10.1002/bit.22961 |
| PMID | 20939009 |
| MeSH | Animals Cell Differentiation* Neurons / physiology* PC12 Cells Rats Vibration* |
| IF | 4.002 |
| 引用数 | 18 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |