| RRC ID |
18581
|
| Author |
Akiyama K, Tone J, Yamauchi S, Sugahara T, Maruyama M, Kakinuma Y.
|
| Title |
Disruption of ion homeostasis by verrucosin and a related compound.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
We have found that (-)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.
|
| Volume |
75(5)
|
| Pages |
1000-2
|
| Published |
2011-1-1
|
| DOI |
10.1271/bbb.110004
|
| PII |
JST.JSTAGE/bbb/110004
|
| PMID |
21597167
|
| MeSH |
Acridine Orange / metabolism
Cell Line, Tumor
Furans / chemistry*
Furans / pharmacology*
Homeostasis / drug effects*
Humans
Ions / metabolism
Lignans / chemistry*
Lignans / pharmacology*
|
| IF |
1.516
|
| Times Cited |
2
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
H-EMC-SS(RCB0508) |
