RRC ID 18622
Author Tamai R, Sugamata M, Kiyoura Y.
Title Candida albicans enhances invasion of human gingival epithelial cells and gingival fibroblasts by Porphyromonas gingivalis.
Journal Microb. Pathog.
Abstract Although Candida albicans has been isolated from periodontal pockets, its relationship to periodontitis is unclear. In this study, we investigated the effect of C. albicans on the adhesion and invasion of Ca9-22, a human gingival epithelial cell line, and human gingival fibroblasts by Porphyromonas gingivalis. Heat-killed C. albicans and water-soluble mannoprotein-β-glucan complex from C. albicans (CAWS) did not enhance P. gingivalis adhesion or upregulate the expression of β1 integrin and ICAM-1, which are required for P. gingivalis invasion; both the epithelial cells and fibroblasts expressed dectin-1, which recognizes components of the C. albicans cell wall. However, pretreatment of Ca9-22 cells and human gingival fibroblasts with heat-killed C. albicans or CAWS significantly enhanced P. gingivalis invasion. These results suggest that C. albicans may exacerbate infectious disease by enhancing the invasion of host cells by anaerobic bacteria.
Volume 51(4)
Pages 250-4
Published 2011-10
DOI 10.1016/j.micpath.2011.06.009
PII S0882-4010(11)00122-7
PMID 21742026
MeSH Candida albicans / pathogenicity* Cell Line Epithelial Cells / microbiology* Fibroblasts / microbiology* Gingiva / microbiology* Humans Microbial Interactions* Porphyromonas gingivalis / pathogenicity*
IF 2.332
Times Cited 16
WOS Category MICROBIOLOGY IMMUNOLOGY
Resource
Human and Animal Cells Ca9-22 (RCB1976)