| RRC ID |
18703
|
| Author |
Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
|
| Title |
Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.
|
| Journal |
Biol Pharm Bull
|
| Abstract |
We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
|
| Volume |
33(1)
|
| Pages |
122-4
|
| Published |
2010-1-1
|
| DOI |
10.1248/bpb.33.122
|
| PII |
JST.JSTAGE/bpb/33.122
|
| PMID |
20045948
|
| MeSH |
Animals
Cell Line, Tumor
Diospyros / chemistry*
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Fruit
Glucosides
Melanins / biosynthesis*
Mice
Monophenol Monooxygenase / metabolism*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Quercetin / analogs & derivatives
|
| IF |
1.863
|
| Times Cited |
23
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
