Reference - Detail
| RRC ID | 18703 |
|---|---|
| Author | Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M. |
| Title | Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis. |
| Journal | Biol Pharm Bull |
| Abstract |
We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression. |
| Volume | 33(1) |
| Pages | 122-4 |
| Published | 2010-1-1 |
| DOI | 10.1248/bpb.33.122 |
| PII | JST.JSTAGE/bpb/33.122 |
| PMID | 20045948 |
| MeSH | Animals Cell Line, Tumor Diospyros / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* Fruit Glucosides Melanins / biosynthesis* Mice Monophenol Monooxygenase / metabolism* Plant Extracts / chemistry Plant Extracts / pharmacology* Quercetin / analogs & derivatives |
| IF | 1.863 |
| Times Cited | 23 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |