RRC ID 18713
Author Ampasavate C, Sotanaphun U, Phattanawasin P, Piyapolrungroj N.
Title Effects of Curcuma spp. on P-glycoprotein function.
Journal Phytomedicine
Abstract The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by both Curcuma longa and Curcuma sp. "khamin-oi" extracts, indicating their roles on efflux transporters. The a-b transport of daunorubicin was increased by curcumin, demethoxycurcumin and bisdemethoxycurcumin while the b-a transport was significantly decreased by curcumin and demethoxycurcumin. However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin. These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP. Taken together, the information may indicate the impact of Curcuma longa and Curcuma sp. "khamin-oi" on pharmacokinetics of orally administered drugs that are P-gp substrates.
Volume 17(7)
Pages 506-12
Published 2010-6
DOI 10.1016/j.phymed.2009.09.004
PII S0944-7113(09)00230-X
PMID 19879740
MeSH ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism* Animals Caco-2 Cells Cell Line Curcuma / chemistry* Curcumin / analogs & derivatives Curcumin / pharmacology* Daunorubicin / pharmacokinetics Dose-Response Relationship, Drug Drug Resistance Fluoresceins / pharmacokinetics Herb-Drug Interactions* Humans Plant Extracts / pharmacology* Rhodamines / pharmacokinetics Swine
IF 3.61
Times Cited 15
Human and Animal Cells LLC-GA5-CoL300 (RCB0872)