論文 - 詳細
| RRC ID | 18713 |
|---|---|
| 著者 | Ampasavate C, Sotanaphun U, Phattanawasin P, Piyapolrungroj N. |
| タイトル | Effects of Curcuma spp. on P-glycoprotein function. |
| ジャーナル | Phytomedicine |
| Abstract |
The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by both Curcuma longa and Curcuma sp. "khamin-oi" extracts, indicating their roles on efflux transporters. The a-b transport of daunorubicin was increased by curcumin, demethoxycurcumin and bisdemethoxycurcumin while the b-a transport was significantly decreased by curcumin and demethoxycurcumin. However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin. These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP. Taken together, the information may indicate the impact of Curcuma longa and Curcuma sp. "khamin-oi" on pharmacokinetics of orally administered drugs that are P-gp substrates. |
| 巻・号 | 17(7) |
| ページ | 506-12 |
| 公開日 | 2010-6-1 |
| DOI | 10.1016/j.phymed.2009.09.004 |
| PII | S0944-7113(09)00230-X |
| PMID | 19879740 |
| MeSH | ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism* Animals Caco-2 Cells Cell Line Curcuma / chemistry* Curcumin / analogs & derivatives Curcumin / pharmacology* Daunorubicin / pharmacokinetics Dose-Response Relationship, Drug Drug Resistance Fluoresceins / pharmacokinetics Herb-Drug Interactions* Humans Plant Extracts / pharmacology* Rhodamines / pharmacokinetics Swine |
| IF | 4.268 |
| 引用数 | 30 |
| WOS 分野 | PLANT SCIENCES PHARMACOLOGY & PHARMACY INTEGRATIVE & COMPLEMENTARY MEDICINE CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC-GA5-CoL300(RCB0872) |