| RRC ID |
18713
|
| 著者 |
Ampasavate C, Sotanaphun U, Phattanawasin P, Piyapolrungroj N.
|
| タイトル |
Effects of Curcuma spp. on P-glycoprotein function.
|
| ジャーナル |
Phytomedicine
|
| Abstract |
The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by both Curcuma longa and Curcuma sp. "khamin-oi" extracts, indicating their roles on efflux transporters. The a-b transport of daunorubicin was increased by curcumin, demethoxycurcumin and bisdemethoxycurcumin while the b-a transport was significantly decreased by curcumin and demethoxycurcumin. However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin. These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP. Taken together, the information may indicate the impact of Curcuma longa and Curcuma sp. "khamin-oi" on pharmacokinetics of orally administered drugs that are P-gp substrates.
|
| 巻・号 |
17(7)
|
| ページ |
506-12
|
| 公開日 |
2010-6-1
|
| DOI |
10.1016/j.phymed.2009.09.004
|
| PII |
S0944-7113(09)00230-X
|
| PMID |
19879740
|
| MeSH |
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
Animals
Caco-2 Cells
Cell Line
Curcuma / chemistry*
Curcumin / analogs & derivatives
Curcumin / pharmacology*
Daunorubicin / pharmacokinetics
Dose-Response Relationship, Drug
Drug Resistance
Fluoresceins / pharmacokinetics
Herb-Drug Interactions*
Humans
Plant Extracts / pharmacology*
Rhodamines / pharmacokinetics
Swine
|
| IF |
4.268
|
| 引用数 |
30
|
|
WOS 分野
|
PLANT SCIENCES
PHARMACOLOGY & PHARMACY
INTEGRATIVE & COMPLEMENTARY MEDICINE
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
LLC-GA5-CoL300(RCB0872) |
