論文 - 詳細
| RRC ID | 18915 |
|---|---|
| 著者 | Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y. |
| タイトル | NOD1 and NOD2 mediate sensing of periodontal pathogens. |
| ジャーナル | J Dent Res |
| Abstract |
In bacterial infection, Nucleotide-binding Oligomerization Domain (NOD) 1 and NOD2 induce innate immune responses by recognizing fragments of the bacterial component peptidoglycan (PGN). To determine the roles of these receptors in detection of periodontal pathogens, we stimulated human embryonic kidney cells expressing NOD1 or NOD2 with heat-killed Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum or their soluble PGNs (sPGNs). All bacteria and their sPGNs could stimulate activation of NF-kappaB. However, there were differences in NOD1- and NOD2-stimulatory activities among the species of bacteria. P. gingivalis showed weaker NOD1- and NOD2-stimulatory activities than did other bacteria. These differences in activities were confirmed by production of interleukin-8 from oral epithelial cells stimulated with sPGNs. These findings indicate that both NOD1 and NOD2 might be involved in the recognition of periodontal pathogens, and that the weak NOD-stimulatory property of P. gingivalis might be helpful for survival in the periodontal pocket. |
| 巻・号 | 89(2) |
| ページ | 186-91 |
| 公開日 | 2010-2-1 |
| DOI | 10.1177/0022034509354843 |
| PII | 0022034509354843 |
| PMID | 20040739 |
| PMC | PMC3318064 |
| MeSH | Aggregatibacter actinomycetemcomitans / immunology Cell Line Chronic Periodontitis / immunology* Chronic Periodontitis / microbiology* Fusobacterium nucleatum / immunology Humans Immune Evasion Interleukin-8 / biosynthesis Kidney / cytology Kidney / embryology Lipid A / immunology NF-kappa B / metabolism Nod1 Signaling Adaptor Protein / immunology* Nod2 Signaling Adaptor Protein / immunology* Peptidoglycan / immunology Porphyromonas gingivalis / immunology* |
| IF | 4.914 |
| 引用数 | 29 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HSC-2(RCB1945) |