論文 - 詳細
| RRC ID | 18941 |
|---|---|
| 著者 | Rincón C, Meredith JC. |
| タイトル | Osteoblast adhesion and proliferation on poly(3-octylthiophene) thin films. |
| ジャーナル | Macromol Biosci |
| Abstract |
In this study we assessed the suitability of semiconducting P3OT thin films (30 nm) to sustain attachment, spreading, and proliferation of MC3T3-E1 osteoblasts. Cell area correlated with surface wettability: area was larger on the more hydrophilic surface (TCPS) and lower on the more hydrophobic surface (P3OT). Cells were rounder, characterized by higher circularity values, on TCPS and Si compared to P3OT. P3OT proliferation rate at 24 h fell twofold after 48 h, then recovered at 72 h to a value significantly higher than that on TCPS. Presoaking experiments showed no evidence of cytotoxic effects or leachants from P3OT. Overall, we conclude that P3OT is a viable substrate for osteoblast attachment and proliferation. |
| 巻・号 | 10(3) |
| ページ | 258-64 |
| 公開日 | 2010-3-10 |
| DOI | 10.1002/mabi.200900243 |
| PMID | 20014196 |
| MeSH | Actins / metabolism Animals Bromodeoxyuridine / metabolism Cell Adhesion / drug effects Cell Movement / drug effects Cell Proliferation / drug effects Mice Osteoblasts / cytology* Osteoblasts / drug effects* Photoelectron Spectroscopy Polymers / chemistry Polymers / pharmacology* Surface Properties / drug effects Thiophenes / chemistry Thiophenes / pharmacology* Water / chemistry |
| IF | 3.416 |
| 引用数 | 6 |
| WOS 分野 | POLYMER SCIENCE BIOCHEMISTRY & MOLECULAR BIOLOGY MATERIALS SCIENCE, BIOMATERIALS |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |