論文 - 詳細
| RRC ID | 18979 |
|---|---|
| 著者 | Rincón C, Chen CC, Meredith JC. |
| タイトル | Effect of poly(3-octylthiophene) doping on the attachment and proliferation of osteoblasts. |
| ジャーナル | Macromol Biosci |
| Abstract |
The effect of doping P3OT with ferric chloride on the attachment and proliferation of MC3T3-E1 osteoblasts is reported. Cell density and area correlated strongly with doping concentration: cells were larger and exhibited better spreading as doping increased. Cells cultured on undoped P3OT showed a decrease in proliferation between 24 and 48 h followed by a recovery after 72 h. However, this trend diminished with increasing doping concentration, and disappeared completely at the highest dopant level investigated. Analysis of cell-cell spatial distributions suggested that contact inhibition of proliferation occurred similarly on both undoped and doped P3OT. From these results, FeCl(3)-doping had no significant deleterious effect on attachment or proliferation of osteoblasts in vitro. |
| 巻・号 | 10(12) |
| ページ | 1536-43 |
| 公開日 | 2010-12-8 |
| DOI | 10.1002/mabi.201000172 |
| PMID | 20803603 |
| MeSH | Animals Cell Adhesion / drug effects* Cell Adhesion / physiology Cell Line Cell Proliferation / drug effects* Chlorides / pharmacology* Contact Inhibition / physiology Dose-Response Relationship, Drug Ferric Compounds / pharmacology* Mice Microscopy, Fluorescence Osteoblasts / physiology* Polymers / pharmacology* Thiophenes / pharmacology* |
| IF | 3.416 |
| 引用数 | 4 |
| WOS 分野 | POLYMER SCIENCE BIOCHEMISTRY & MOLECULAR BIOLOGY MATERIALS SCIENCE, BIOMATERIALS |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |