RRC ID |
18981
|
著者 |
Mori Y, Yano F, Shimohata N, Suzuki S, Chung UI, Takato T.
|
タイトル |
Trehalose inhibits oral dryness by protecting the cell membrane.
|
ジャーナル |
Int J Oral Maxillofac Surg
|
Abstract |
This study assessed the clinical efficacy and acceptability of trehalose solution for oral dryness caused by dental treatment. The efficacy of trehalose on oral dryness under drying conditions was assessed by measuring the surface area of the fungiform papillae and the moisture content of the tongue in seven healthy volunteers. Based on the data from this pilot study, a clinical study was performed, in which the efficacy of oral trehalose spray was evaluated on oral dryness in 10 patients undergoing root canal treatment. The effects of trehalose on cell viability were also assessed under drying conditions in vitro. Trehalose suppressed oral dryness and associated pain caused by dental treatment and protected cells from dryness-related damage. These results indicate that pretreatment application of trehalose solution on the oral mucosa is effective in preventing oral dryness caused by dental treatment.
|
巻・号 |
39(9)
|
ページ |
916-21
|
公開日 |
2010-9-1
|
DOI |
10.1016/j.ijom.2010.04.047
|
PII |
S0901-5027(10)00194-3
|
PMID |
20605407
|
MeSH |
Adult
Aged
Cell Survival / drug effects
Desiccation
Disaccharides / therapeutic use*
Female
Humans
Male
Middle Aged
Mouth Mucosa / drug effects*
Pilot Projects
Reference Values
Root Canal Therapy / adverse effects*
Root Canal Therapy / instrumentation
Statistics, Nonparametric
Suction / adverse effects
Surface Properties
Trehalose / therapeutic use*
Tumor Cells, Cultured / drug effects
Xerostomia / etiology
Xerostomia / prevention & control*
Young Adult
|
IF |
2.068
|
引用数 |
8
|
WOS 分野
|
SURGERY
DENTISTRY, ORAL SURGERY & MEDICINE
|
リソース情報 |
ヒト・動物細胞 |
Ca9-22(RCB1976) |