RRC ID 18981
Author Mori Y, Yano F, Shimohata N, Suzuki S, Chung UI, Takato T.
Title Trehalose inhibits oral dryness by protecting the cell membrane.
Journal Int J Oral Maxillofac Surg
Abstract This study assessed the clinical efficacy and acceptability of trehalose solution for oral dryness caused by dental treatment. The efficacy of trehalose on oral dryness under drying conditions was assessed by measuring the surface area of the fungiform papillae and the moisture content of the tongue in seven healthy volunteers. Based on the data from this pilot study, a clinical study was performed, in which the efficacy of oral trehalose spray was evaluated on oral dryness in 10 patients undergoing root canal treatment. The effects of trehalose on cell viability were also assessed under drying conditions in vitro. Trehalose suppressed oral dryness and associated pain caused by dental treatment and protected cells from dryness-related damage. These results indicate that pretreatment application of trehalose solution on the oral mucosa is effective in preventing oral dryness caused by dental treatment.
Volume 39(9)
Pages 916-21
Published 2010-9
DOI 10.1016/j.ijom.2010.04.047
PII S0901-5027(10)00194-3
PMID 20605407
MeSH Adult Aged Cell Survival / drug effects Desiccation Disaccharides / therapeutic use* Female Humans Male Middle Aged Mouth Mucosa / drug effects* Pilot Projects Reference Values Root Canal Therapy / adverse effects* Root Canal Therapy / instrumentation Statistics, Nonparametric Suction / adverse effects Surface Properties Trehalose / therapeutic use* Tumor Cells, Cultured / drug effects Xerostomia / etiology Xerostomia / prevention & control* Young Adult
IF 2.164
Times Cited 7
Human and Animal Cells Ca9-22 (RCB1976)