| RRC ID |
19003
|
| 著者 |
Kitano Y, Murazumi K, Duan J, Kurose K, Kobayashi S, Sugawara T, Hirata T.
|
| タイトル |
Effect of dietary porphyran from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice.
|
| ジャーナル |
J Nutr Sci Vitaminol (Tokyo)
|
| Abstract |
Porphyran (POR) from the red alga Porphyra yezoensis is a water soluble dietary fiber. In this study, we investigated the effect of dietary POR on glucose metabolism in KK-Ay mice (a model for type 2 diabetes). Mice were divided into 4 groups and fed a diet containing 5% cellulose (control), POR, POR Arg or POR K. After 3 wk of feeding, plasma insulin levels and the calculated homeostasis model assessment-insulin resistance (HOMA-IR) index were significantly lower in the POR group than in the control group. Compared with the control group, plasma adiponectin levels were significantly increased in the POR, POR Arg and POR K groups. These results suggest that dietary POR should improve glucose metabolism in diabetes via up-regulation of adiponectin levels. In addition, the amount of propionic acid in the cecum of the POR group was significantly higher than in the control group and the profile of bacterial flora was changed by dietary POR. In the cecum of the POR, POR Arg and POR K groups, Bacteroides was significantly increased and Clostridium coccoides was significantly decreased compared with in the control group. The effects of dietary POR on the hindgut environment might contribute to the improvement of glucose metabolism.
|
| 巻・号 |
58(1)
|
| ページ |
14-9
|
| 公開日 |
2012-1-1
|
| DOI |
10.3177/jnsv.58.14
|
| PII |
DN/JST.JSTAGE/jnsv/58.14
|
| PMID |
23007062
|
| MeSH |
Adiponectin / blood
Animals
Cecum / metabolism
Cecum / microbiology
Cholesterol / blood
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / metabolism*
Dietary Fiber / pharmacology*
Disease Models, Animal
Fatty Acids, Nonesterified / blood
Glucose / metabolism*
Insulin / blood
Insulin Resistance
Male
Mice
Porphyra / chemistry*
RNA, Bacterial / chemistry
RNA, Bacterial / genetics
Real-Time Polymerase Chain Reaction
Sepharose / analogs & derivatives*
Sepharose / pharmacology
Triglycerides / blood
|
| IF |
1.424
|
| 引用数 |
25
|
|
WOS 分野
|
NUTRITION & DIETETICS
|
| リソース情報 |
| 一般微生物 |
JCM 1034
JCM 1200
JCM 1395
JCM 5827
JCM 7786 |
