RRC ID 19003
Author Kitano Y, Murazumi K, Duan J, Kurose K, Kobayashi S, Sugawara T, Hirata T.
Title Effect of dietary porphyran from the red alga, Porphyra yezoensis, on glucose metabolism in diabetic KK-Ay mice.
Journal J. Nutr. Sci. Vitaminol.
Abstract Porphyran (POR) from the red alga Porphyra yezoensis is a water soluble dietary fiber. In this study, we investigated the effect of dietary POR on glucose metabolism in KK-Ay mice (a model for type 2 diabetes). Mice were divided into 4 groups and fed a diet containing 5% cellulose (control), POR, POR Arg or POR K. After 3 wk of feeding, plasma insulin levels and the calculated homeostasis model assessment-insulin resistance (HOMA-IR) index were significantly lower in the POR group than in the control group. Compared with the control group, plasma adiponectin levels were significantly increased in the POR, POR Arg and POR K groups. These results suggest that dietary POR should improve glucose metabolism in diabetes via up-regulation of adiponectin levels. In addition, the amount of propionic acid in the cecum of the POR group was significantly higher than in the control group and the profile of bacterial flora was changed by dietary POR. In the cecum of the POR, POR Arg and POR K groups, Bacteroides was significantly increased and Clostridium coccoides was significantly decreased compared with in the control group. The effects of dietary POR on the hindgut environment might contribute to the improvement of glucose metabolism.
Volume 58(1)
Pages 14-9
Published 2012
DOI 10.3177/jnsv.58.14
PII DN/JST.JSTAGE/jnsv/58.14
PMID 23007062
MeSH Adiponectin / blood Animals Cecum / metabolism Cecum / microbiology Cholesterol / blood Diabetes Mellitus, Type 2 / blood Diabetes Mellitus, Type 2 / drug therapy* Diabetes Mellitus, Type 2 / metabolism* Dietary Fiber / pharmacology* Disease Models, Animal Fatty Acids, Nonesterified / blood Glucose / metabolism* Insulin / blood Insulin Resistance Male Mice Porphyra / chemistry* RNA, Bacterial / chemistry RNA, Bacterial / genetics Real-Time Polymerase Chain Reaction Sepharose / analogs & derivatives* Sepharose / pharmacology Triglycerides / blood
IF 1.125
Times Cited 10
General Microbes JCM 1034 JCM 1200 JCM 1395 JCM 5827 JCM 7786