Reference - Detail
| RRC ID | 1920 |
|---|---|
| Author | Shoji T, Masumoto S, Moriichi N, Kobori M, Kanda T, Shinmoto H, Tsushida T. |
| Title | Procyanidin trimers to pentamers fractionated from apple inhibit melanogenesis in B16 mouse melanoma cells. |
| Journal | J Agric Food Chem |
| Abstract |
The effects of apple polyphenols on melanogenesis in B16 mouse melanoma cells were investigated. The inhibitory effect of apple polyphenols was stronger than that of arbutin or kojic acid. Three polyphenol fractions (phenolic acid derivatives, procyanidins and other flavonoids) were isolated, and the procyanidins were fractionated according to the degree of polymerization using normal-phase chromatography. The procyanidin trimer-to-pentamer fractions were found to have the most pronounced effect on melanogenesis. Furthermore, each procyanidin fraction inhibited mushroom tyrosinase. No correlation between the degree of procyanidin polymerization and tyrosinase inhibitory activity was observed. Nevertheless, these observations suggest that procyanidins are effective inhibitors of tyrosinase. |
| Volume | 53(15) |
| Pages | 6105-11 |
| Published | 2005-7-27 |
| DOI | 10.1021/jf050418m |
| PMID | 16029003 |
| MeSH | Animals Enzyme Inhibitors / pharmacology Flavonoids / pharmacology Fruit / chemistry* Malus / chemistry* Melanins / biosynthesis* Melanoma, Experimental Mice Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / metabolism Phenols / pharmacology Polymers / chemistry Polyphenols Proanthocyanidins / chemistry* Proanthocyanidins / pharmacology* |
| IF | 4.192 |
| Times Cited | 58 |
| WOS Category | AGRICULTURE, MULTIDISCIPLINARY CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY |
| Altmetric score |
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| The most frequently cited source | Google+ |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |