RRC ID 1921
Author Kuang M, Liu SQ, Saijo K, Uchimura E, Huang L, Leong KW, Lu MD, Huang JF, Ohno T.
Title Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.
Journal Int J Hyperthermia
Abstract After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.
Volume 21(3)
Pages 247-57
Published 2005-5
DOI 10.1080/02656730500052027
PII TG267T0N508P8533
PMID 16019851
MeSH Animals CD3 Complex / immunology Cancer Vaccines* Carcinoma, Lewis Lung / pathology Carcinoma, Lewis Lung / radiotherapy* Carcinoma, Lewis Lung / surgery Cell Line, Tumor Electrocoagulation / methods* Female Graft Rejection Granulocyte-Macrophage Colony-Stimulating Factor / genetics Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology Humans Interleukin-2 / genetics Interleukin-2 / pharmacology Killer Cells, Natural / immunology Lung Neoplasms / pathology Lung Neoplasms / radiotherapy* Lung Neoplasms / surgery Male Mice Mice, Inbred C57BL Microspheres Microwaves / therapeutic use* Neoplasm Transplantation Recombinant Proteins / pharmacology T-Lymphocytes, Cytotoxic / immunology Tumor Burden
IF 3.44
Times Cited 8
Human and Animal Cells LLC Hepa 1-6