RRC ID |
1921
|
著者 |
Kuang M, Liu SQ, Saijo K, Uchimura E, Huang L, Leong KW, Lu MD, Huang JF, Ohno T.
|
タイトル |
Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.
|
ジャーナル |
Int J Hyperthermia
|
Abstract |
After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use.
|
巻・号 |
21(3)
|
ページ |
247-57
|
公開日 |
2005-5-1
|
DOI |
10.1080/02656730500052027
|
PII |
TG267T0N508P8533
|
PMID |
16019851
|
MeSH |
Animals
CD3 Complex / immunology
Cancer Vaccines*
Carcinoma, Lewis Lung / pathology
Carcinoma, Lewis Lung / radiotherapy*
Carcinoma, Lewis Lung / surgery
Cell Line, Tumor
Electrocoagulation / methods*
Female
Graft Rejection
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
Humans
Interleukin-2 / genetics
Interleukin-2 / pharmacology
Killer Cells, Natural / immunology
Lung Neoplasms / pathology
Lung Neoplasms / radiotherapy*
Lung Neoplasms / surgery
Male
Mice
Mice, Inbred C57BL
Microspheres
Microwaves / therapeutic use*
Neoplasm Transplantation
Recombinant Proteins / pharmacology
T-Lymphocytes, Cytotoxic / immunology
Tumor Burden
|
IF |
3.574
|
引用数 |
10
|
WOS 分野
|
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
LLC(RCB0558)
Hepa 1-6(RCB1638) |