論文 - 詳細
| RRC ID | 1921 |
|---|---|
| 著者 | Kuang M, Liu SQ, Saijo K, Uchimura E, Huang L, Leong KW, Lu MD, Huang JF, Ohno T. |
| タイトル | Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity. |
| ジャーナル | Int J Hyperthermia |
| Abstract |
After local microwave coagulation and subsequent intra-tumoural injection of microparticles encapsulating interleukin-2 and granulocyte-macrophage colony-stimulating factor, the anti-tumour efficacy against subcutaneous Lewis lung carcinoma in syngeneic mice was evaluated. This treatment elicited a potent systemic anti-tumour immunity that protected treated mice from re-challenge with the same tumour cells and caused the distal tumours in a bilateral tumour model to be rejected. Cytotoxicity assay indicated that both T- and natural killer cells acted as the effector cells in the anti-tumour immunity. These data highlight the feasibility of microwave-pre-treated in situ cancer vaccination for clinical use. |
| 巻・号 | 21(3) |
| ページ | 247-57 |
| 公開日 | 2005-5-1 |
| DOI | 10.1080/02656730500052027 |
| PII | TG267T0N508P8533 |
| PMID | 16019851 |
| MeSH | Animals CD3 Complex / immunology Cancer Vaccines* Carcinoma, Lewis Lung / pathology Carcinoma, Lewis Lung / radiotherapy* Carcinoma, Lewis Lung / surgery Cell Line, Tumor Electrocoagulation / methods* Female Graft Rejection Granulocyte-Macrophage Colony-Stimulating Factor / genetics Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology Humans Interleukin-2 / genetics Interleukin-2 / pharmacology Killer Cells, Natural / immunology Lung Neoplasms / pathology Lung Neoplasms / radiotherapy* Lung Neoplasms / surgery Male Mice Mice, Inbred C57BL Microspheres Microwaves / therapeutic use* Neoplasm Transplantation Recombinant Proteins / pharmacology T-Lymphocytes, Cytotoxic / immunology Tumor Burden |
| IF | 3.574 |
| 引用数 | 10 |
| WOS 分野 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) Hepa 1-6(RCB1638) |