論文 - 詳細
| RRC ID | 19269 |
|---|---|
| 著者 | Yasuda K, Kitamura N, Gong JP, Arakaki K, Kwon HJ, Onodera S, Chen YM, Kurokawa T, Kanaya F, Ohmiya Y, Osada Y. |
| タイトル | A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect. |
| ジャーナル | Macromol Biosci |
| Abstract |
We have developed a novel method to induce spontaneous hyaline cartilage regeneration in vivo for a large osteochondral defect by implanting a plug made from a double-network hydrogel composed of poly(2-acrylamido-2-methylpropanesulfonic acid) and poly(N,N'-dimethylacrylamide) at the bottom of the defect, leaving the cavity vacant. In cells regenerated in the treated defect, type-2 collagen, Aggrican, and SOX9 mRNAs were highly expressed and the regenerated matrix was rich in proteoglycan and type-2 collagen at 4 weeks. This fact gave a significant modification to the commonly established concept that hyaline cartilage tissue cannot regenerate in vivo. This study prompted an innovative strategy in the field of joint surgery to repair an osteochondral defect using an advanced, high-function hydrogel. |
| 巻・号 | 9(4) |
| ページ | 307-16 |
| 公開日 | 2009-4-8 |
| DOI | 10.1002/mabi.200800223 |
| PMID | 19031389 |
| MeSH | Acrylamides / chemistry Acrylamides / therapeutic use* Animals Biocompatible Materials / chemistry Cartilage, Articular / injuries* Cartilage, Articular / physiology* Cell Differentiation / physiology Female Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry Hydrogel, Polyethylene Glycol Dimethacrylate / therapeutic use* Knee Injuries / surgery* Pilot Projects Polymerase Chain Reaction Polymers / chemistry Polymers / therapeutic use* Rabbits Regeneration / physiology* SOX9 Transcription Factor / metabolism Sulfonic Acids / chemistry Sulfonic Acids / therapeutic use* |
| IF | 3.416 |
| 引用数 | 111 |
| WOS 分野 | POLYMER SCIENCE BIOCHEMISTRY & MOLECULAR BIOLOGY MATERIALS SCIENCE, BIOMATERIALS |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |