Reference - Detail
| RRC ID | 19281 |
|---|---|
| Author | Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y. |
| Title | A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4). |
| Volume | 73(11) |
| Pages | 2525-7 |
| Published | 2009-11-1 |
| DOI | 10.1271/bbb.90419 |
| PII | JST.JSTAGE/bbb/90419 |
| PMID | 19897905 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology* Ascomycota / chemistry* Cell Proliferation / drug effects HL-60 Cells Humans Leukemia / pathology* Lichens / chemistry* Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology* |
| IF | 1.516 |
| Times Cited | 9 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |