論文 - 詳細
| RRC ID | 1929 |
|---|---|
| 著者 | Moro T, Takatori Y, Ishihara K, Konno T, Takigawa Y, Matsushita T, Chung UI, Nakamura K, Kawaguchi H. |
| タイトル | Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis. |
| ジャーナル | Nat Mater |
| Abstract |
Periprosthetic osteolysis-bone loss in the vicinity of a prosthesis-is the most serious problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to wear particles originating from the articulating surface. This study investigated the effects of graft polymerization of our original biocompatible phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the polyethylene surface. Mechanical studies using a hip-joint simulator revealed that the MPC grafting markedly decreased the friction and the amount of wear. Osteoclastic bone resorption induced by subperiosteal injection of particles onto mouse calvariae was abolished by the MPC grafting on particles. MPC-grafted particles were shown to be biologically inert by culture systems with respect to phagocytosis and resorptive cytokine secretion by macrophages, subsequent expression of receptor activator of NF-kappaB ligand in osteoblasts, and osteoclastogenesis from bone marrow cells. From the mechanical and biological advantages, we believe that our approach will make a major improvement in artificial joints by preventing periprosthetic osteolysis. |
| 巻・号 | 3(11) |
| ページ | 829-36 |
| 公開日 | 2004-11-1 |
| DOI | 10.1038/nmat1233 |
| PII | nmat1233 |
| PMID | 15502835 |
| MeSH | Biocompatible Materials* Joint Prosthesis* Methacrylates* Osteolysis* Phosphorylcholine* / analogs & derivatives* Surface Properties |
| IF | 38.663 |
| 引用数 | 408 |
| WOS 分野 | MATERIALS SCIENCE, MULTIDISCIPLINARY PHYSICS, APPLIED PHYSICS, CONDENSED MATTER CHEMISTRY, PHYSICAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |