論文 - 詳細
| RRC ID | 19296 |
|---|---|
| 著者 | Nagano-Ito M, Banba A, Ichikawa S. |
| タイトル | Functional cloning of genes that suppress oxidative stress-induced cell death: TCTP prevents hydrogen peroxide-induced cell death. |
| ジャーナル | FEBS Lett |
| Abstract |
We used retroviral-mediated expression cloning to identify cDNAs that inhibit cell death induced by oxidative stress. To isolate the genes, we introduced a murine embryonic retroviral cDNA library into NIH/3T3 cells, and selected for cells resistant to hydrogen peroxide. The surviving cells were cloned, and the integrated cDNAs were rescued by polymerase chain reaction. Several of the isolated cDNAs are known to be involved in modulating the redox state of cells. Other cDNAs encode proteins known to suppress apoptosis caused by reasons other than oxidative stress. These included polyadenylate-binding protein, cytosolic 1 (Pabpc1) and translationally controlled tumor protein (TCTP). |
| 巻・号 | 583(8) |
| ページ | 1363-7 |
| 公開日 | 2009-4-17 |
| DOI | 10.1016/j.febslet.2009.03.045 |
| PII | S0014-5793(09)00237-3 |
| PMID | 19328788 |
| MeSH | Animals Base Sequence Biomarkers, Tumor / physiology* Cell Death / drug effects* Cloning, Molecular DNA Primers DNA, Complementary Hydrogen Peroxide / pharmacology* Mice NIH 3T3 Cells Oxidative Stress* Tumor Protein, Translationally-Controlled 1 |
| IF | 3.057 |
| 引用数 | 19 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-1(RCB0143) |