Reference - Detail
| RRC ID | 19318 |
|---|---|
| Author | Nakayasu S, Soegima R, Yamaguchi K, Oda T. |
| Title | Biological activities of fucose-containing polysaccharide ascophyllan isolated from the brown alga Ascophyllum nodosum. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
A fucose-containing, sulfated polysaccharide ascophyllan was isolated from the brown alga Ascophyllum nodosum. Composition analysis demonstrated that ascophyllan mainly contains uronic acid, xylose, fucose, and sulfate half ester in approximately equimolecular proportions, which are evidently distinct from those of alginate and fucoidan. Ascophyllan inhibited the proliferation of U937 cells in a concentration-dependent manner, and DNA-fragmentation and typical apoptotic nuclear morphological changes were observed in the ascophyllan-treated cells. Furthermore, ascophyllan induced the secretion of tumor necrosis factor-alpha (TNF-alpha) and granulocyte colony-stimulating factor (G-CSF) from mouse macrophage cell line RAW264.7. |
| Volume | 73(4) |
| Pages | 961-4 |
| Published | 2009-4-23 |
| DOI | 10.1271/bbb.80845 |
| PII | JST.JSTAGE/bbb/80845 |
| PMID | 19352011 |
| MeSH | Ascophyllum / chemistry* Cell Line, Tumor Cell Proliferation / drug effects Cytokines / metabolism Fucose / chemistry* Humans Polysaccharides / chemistry* Polysaccharides / isolation & purification Polysaccharides / pharmacology* |
| IF | 1.516 |
| Times Cited | 50 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | U-937 DE-4(RCB0435) |