論文 - 詳細
| RRC ID | 19327 |
|---|---|
| 著者 | Ohguchi K, Ito M, Yokoyama K, Iinuma M, Itoh T, Nozawa Y, Akao Y. |
| タイトル | Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
In this study, we examined the effect of sesquiterpene lactones isolated from Calea urticifolia and Tanacetum parthenium (feverfew) on melanogenesis in mouse B16 melanoma cells. In response to 3-isobutyl-1-methylxanthin (IBMX), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. Treatment of sesquiterpene lactones at lower concentration (1 microM) significantly blocked IBMX-induced melanogenesis, but did not induce the inhibitory activity of cell growth. Among them, 2,3-epoxyjuanislamin exhibited a potent inhibitory effect on melanogenesis. Treatment of B16 cells with 2,3-epoxyjuanislamin elicited significant decreases in tyrosinase protein and mRNA levels. These results demonstrated that the inhibitory effects of sesquiterpene lactones on melanin biosynthesis may be due to the suppression of tyrosinase expression. |
| 巻・号 | 32(2) |
| ページ | 308-10 |
| 公開日 | 2009-2-1 |
| DOI | 10.1248/bpb.32.308 |
| PII | JST.JSTAGE/bpb/32.308 |
| PMID | 19182396 |
| MeSH | 1-Methyl-3-isobutylxanthine / antagonists & inhibitors 1-Methyl-3-isobutylxanthine / pharmacology Animals Asteraceae / chemistry Blotting, Western Cell Line, Tumor Cell Survival / drug effects Lactones / pharmacology* Melanins / biosynthesis* Melanoma, Experimental / metabolism* Mice Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / metabolism Phosphodiesterase Inhibitors / pharmacology Plant Extracts / chemistry Plant Extracts / pharmacology Plant Leaves / chemistry Reverse Transcriptase Polymerase Chain Reaction Sesquiterpenes / pharmacology* Structure-Activity Relationship Tanacetum / chemistry |
| IF | 1.863 |
| 引用数 | 21 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |