| RRC ID |
19334
|
| Author |
Ishii M, Kobayashi S, Ohkura M, Yamamoto R, Shimizu S, Kiuchi Y.
|
| Title |
Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.
|
| Journal |
J Pharmacol Sci
|
| Abstract |
We examined the effects of lomerizine on serotonin (5-hydroxytryptamine, 5-HT)-induced contraction of the basilar artery and compared them with those of nifedipine. Although both lomerizine and nifedipine completely blocked K(+)-induced vasoconstriction, 5-HT-induced vasoconstriction was more strongly inhibited by lomerizine than nifedipine. A 5-HT(2A) antagonist inhibited the 5-HT-induced vasoconstriction, but a 5-HT(1B) antagonist did not. Lomerizine, but not nifedipine, suppressed 5-HT-induced Ca(2+) release in 5-HT(2A)-expressing HEK293 cells. Moreover, neither antagonist affected ATP-induced Ca(2+) release. These results suggest that lomerizine may inhibit not only voltage-dependent Ca(2+) channels but also 5-HT(2A) receptors and so inhibit 5-HT-induced contraction in the basilar artery.
|
| Volume |
111(2)
|
| Pages |
221-5
|
| Published |
2009-10-1
|
| DOI |
10.1254/jphs.09205sc
|
| PII |
JST.JSTAGE/jphs/09205SC
|
| PMID |
19783864
|
| MeSH |
Animals
Basilar Artery / drug effects*
Basilar Artery / metabolism
Calcium Channel Blockers / pharmacology*
Male
Migraine Disorders / prevention & control*
Piperazines / pharmacology*
Rats
Rats, Wistar
Serotonin / pharmacology*
Vasoconstriction / drug effects*
|
| IF |
2.835
|
| Times Cited |
13
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| Human and Animal Cells |
293(RCB1637) |
