Reference - Detail
| RRC ID | 19384 |
|---|---|
| Author | Oura R, Arakaki R, Yamada A, Kudo Y, Tanaka E, Hayashi Y, Ishimaru N. |
| Title | Induction of rapid T cell death and phagocytic activity by Fas-deficient lpr macrophages. |
| Journal | J Immunol |
| Abstract |
Peripheral T cells are maintained by the apoptosis of activated T cells through the Fas-Fas ligand system. Although it is well known that normal T cells fail to survive in the Fas-deficient immune condition, the molecular mechanism for the phenomenon has yet to be elucidated. In this study, we demonstrate that rapid cell death and clearance of normal T cells were induced by Fas-deficient lpr macrophages. Transfer of normal T cells into lpr mice revealed that Fas expression on donor T cells was promptly enhanced through the IFN-γ/IFN-γR. In addition, Fas ligand expression and phagocytic activity of lpr macrophages were promoted through increased NF-κB activation. Controlling Fas expression on macrophages plays an essential role in maintaining T cell homeostasis in the peripheral immune system. Our data suggest a critical implication to the therapeutic strategies such as transplantation and immunotherapy for immune disorder or autoimmunity related to abnormal Fas expression. |
| Volume | 190(2) |
| Pages | 578-85 |
| Published | 2013-1-15 |
| DOI | 10.4049/jimmunol.1103794 |
| PII | jimmunol.1103794 |
| PMID | 23255359 |
| PMC | PMC3539689 |
| MeSH | Animals Cell Death / immunology Cell Movement / genetics Cell Movement / immunology Fas Ligand Protein / genetics Fas Ligand Protein / immunology Gene Expression Regulation Immunomodulation / genetics Macrophages / immunology* Macrophages / metabolism* Mice Mice, Inbred MRL lpr Mice, Transgenic NF-kappa B / metabolism Phagocytosis / immunology* T-Lymphocytes / immunology* T-Lymphocytes / metabolism* fas Receptor / deficiency* |
| IF | 4.886 |
| Times Cited | 5 |
| WOS Category | IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Mice | RBRC00267 |