| RRC ID |
19634
|
| 著者 |
Nakamura T, Kodama N, Kumamoto T, Higuchi Y, Chaichantipyuth C, Ueno K, Ishikawa T, Yano S.
|
| タイトル |
Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7.
|
| ジャーナル |
J Nat Med
|
| Abstract |
In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration-dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.
|
| 巻・号 |
63(1)
|
| ページ |
107-10
|
| 公開日 |
2009-1-1
|
| DOI |
10.1007/s11418-008-0276-6
|
| PMID |
18626726
|
| MeSH |
Animals
Blotting, Western
Cell Line
Dose-Response Relationship, Drug
Macrophages / cytology
Macrophages / drug effects*
Macrophages / metabolism
Mice
Nitric Oxide Synthase Type II / metabolism*
Plant Bark / chemistry
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plants, Medicinal / chemistry*
Thailand
|
| IF |
2.055
|
| 引用数 |
2
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
