| RRC ID |
19644
|
| 著者 |
Okamoto A, Ohnishi T, Bandow K, Kakimoto K, Chiba N, Maeda A, Fukunaga T, Miyawaki S, Matsuguchi T.
|
| タイトル |
Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice.
|
| ジャーナル |
Eur J Oral Sci
|
| Abstract |
Orthodontic therapy is known to have an aggravating effect on the progression of destructive periodontitis if oral hygiene is not maintained. However, it is largely unknown how active periodontitis affects the velocity of orthodontic tooth movement. In this study, we examined the effect of periodontal inflammation on orthodontic tooth movement using a mouse model. Orthodontic force was applied on the maxillary first molar of mice, with or without ligature wire to induce experimental periodontitis. The distance moved by the first molar was significantly reduced by the ligature-induced experimental periodontitis. Tartrate-resistant acid phosphatase staining revealed that the number of osteoclasts present during orthodontic treatment was lower in the pressure zone of alveolar bone in the presence of periodontal inflammation. Consistently, the expression level of receptor activator of nuclear factor-kappaB ligand (RANKL) in the pressure zone was decreased in the ligature group. By contrast, experimental periodontitis increased the expression of cyclooxygenase-2 mRNA in the periodontal tissues, while in vitro treatment with prostaglandin E(2) decreased extracellular signal-regulated kinase phosphorylation and RANKL expression induced by mechanical stress in osteoblasts. Taken together, these results suggest that the orthodontic force-induced osteoclastogenesis in alveolar bone was inhibited by the accompanying periodontal inflammation, at least partly through prostaglandin E(2), resulting in reduced orthodontic tooth movement.
|
| 巻・号 |
117(3)
|
| ページ |
238-47
|
| 公開日 |
2009-6-1
|
| DOI |
10.1111/j.1600-0722.2009.00625.x
|
| PII |
EOS625
|
| PMID |
19583750
|
| MeSH |
3T3 Cells
Acid Phosphatase / analysis
Alveolar Bone Loss / pathology
Alveolar Bone Loss / physiopathology
Alveolar Process / pathology
Alveolar Process / physiopathology
Animals
Biomarkers / analysis
Cyclooxygenase 2 / analysis
Dinoprostone / pharmacology
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases / drug effects
Isoenzymes / analysis
Male
Maxilla / pathology
Maxilla / physiopathology
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Molar / physiopathology
Osteoblasts / drug effects
Osteoblasts / pathology
Osteoclasts / pathology
Osteoclasts / physiology
Periodontitis / pathology
Periodontitis / physiopathology*
Phosphorylation
RANK Ligand / analysis
RANK Ligand / drug effects
Stress, Mechanical
Tartrate-Resistant Acid Phosphatase
Tooth Movement Techniques*
|
| IF |
2.22
|
| 引用数 |
19
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
