Reference - Detail
| RRC ID | 19698 |
|---|---|
| Author | Sanei M, Pickering R, Kumke K, Nasuda S, Houben A. |
| Title | Loss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Uniparental chromosome elimination occurs in several interspecific hybrids of plants. We studied the mechanism underlying selective elimination of the paternal chromosomes during the early development of Hordeum vulgare × Hordeum bulbosum embryos. The following conclusions regarding the role of the centromere-specific histone H3 variant (CENH3) in the process of chromosome elimination were drawn: (i) centromere inactivity of H. bulbosum chromosomes triggers the mitosis-dependent process of uniparental chromosome elimination in unstable H. vulgare × H. bulbosum hybrids; (ii) centromeric loss of CENH3 protein rather than uniparental silencing of CENH3 genes causes centromere inactivity; (iii) in stable species combinations, cross-species incorporation of CENH3 occurs despite centromere-sequence differences, and not all CENH3 variants get incorporated into centromeres if multiple CENH3s are present in species combinations; and (iv) diploid barley species encode two CENH3 variants, the proteins of which are intermingled within centromeres throughout mitosis and meiosis. |
| Volume | 108(33) |
| Pages | E498-505 |
| Published | 2011-8-16 |
| DOI | 10.1073/pnas.1103190108 |
| PII | 1103190108 |
| PMID | 21746892 |
| PMC | PMC3158150 |
| MeSH | Centromere / chemistry* Chimera Chromosomes, Plant* Histones / metabolism* Hordeum / genetics* Meiosis Mitosis Molecular Sequence Data Plant Proteins / metabolism Uniparental Disomy |
| IF | 9.412 |
| Times Cited | 139 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 3.0 |
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