論文 - 詳細
| RRC ID | 19834 |
|---|---|
| 著者 | Ishida K, Nakagawa H, Murakami M. |
| タイトル | Microcyclamide, a cytotoxic cyclic hexapeptide from the cyanobacterium Microcystis aeruginosa. |
| ジャーナル | J Nat Prod |
| Abstract |
Microcyclamide (1), a cytotoxic cyclic hexapeptide, was isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-298). Its structure was elucidated to be 1 on the basis of two-dimensional (1)H-(1)H, (1)H-(13)C, and (1)H-(15)N NMR correlation experiments and the HRFABMS measurement. The absolute stereochemistry of the asymmetric centers was determined by the Marfey's method. This peptide showed a moderate cytotoxicity against P388 murine leukemia cells. |
| 巻・号 | 63(9) |
| ページ | 1315-7 |
| 公開日 | 2000-9-1 |
| DOI | 10.1021/np000159p |
| PII | np000159p |
| PMID | 11000050 |
| MeSH | Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Drug Screening Assays, Antitumor Mice Microcystis / chemistry* Oligopeptides / chemistry Oligopeptides / isolation & purification* Oligopeptides / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Protein Conformation Spectrum Analysis Tumor Cells, Cultured |
| IF | 3.782 |
| 引用数 | 57 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-298 |