Reference - Detail
| RRC ID | 19834 |
|---|---|
| Author | Ishida K, Nakagawa H, Murakami M. |
| Title | Microcyclamide, a cytotoxic cyclic hexapeptide from the cyanobacterium Microcystis aeruginosa. |
| Journal | J Nat Prod |
| Abstract |
Microcyclamide (1), a cytotoxic cyclic hexapeptide, was isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-298). Its structure was elucidated to be 1 on the basis of two-dimensional (1)H-(1)H, (1)H-(13)C, and (1)H-(15)N NMR correlation experiments and the HRFABMS measurement. The absolute stereochemistry of the asymmetric centers was determined by the Marfey's method. This peptide showed a moderate cytotoxicity against P388 murine leukemia cells. |
| Volume | 63(9) |
| Pages | 1315-7 |
| Published | 2000-9-1 |
| DOI | 10.1021/np000159p |
| PII | np000159p |
| PMID | 11000050 |
| MeSH | Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Drug Screening Assays, Antitumor Mice Microcystis / chemistry* Oligopeptides / chemistry Oligopeptides / isolation & purification* Oligopeptides / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Protein Conformation Spectrum Analysis Tumor Cells, Cultured |
| IF | 3.782 |
| Times Cited | 57 |
| WOS Category | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Algae | NIES-298 |