RRC ID 19834
Author Ishida K, Nakagawa H, Murakami M.
Title Microcyclamide, a cytotoxic cyclic hexapeptide from the cyanobacterium Microcystis aeruginosa.
Journal J. Nat. Prod.
Abstract Microcyclamide (1), a cytotoxic cyclic hexapeptide, was isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-298). Its structure was elucidated to be 1 on the basis of two-dimensional (1)H-(1)H, (1)H-(13)C, and (1)H-(15)N NMR correlation experiments and the HRFABMS measurement. The absolute stereochemistry of the asymmetric centers was determined by the Marfey's method. This peptide showed a moderate cytotoxicity against P388 murine leukemia cells.
Volume 63(9)
Pages 1315-7
Published 2000-9
PII np000159p
PMID 11000050
MeSH Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Drug Screening Assays, Antitumor Mice Microcystis / chemistry* Oligopeptides / chemistry Oligopeptides / isolation & purification* Oligopeptides / pharmacology Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Protein Conformation Spectrum Analysis Tumor Cells, Cultured
IF 3.885
Times Cited 42
WOS Category CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY PLANT SCIENCES
Resource
Algae NIES-298