| RRC ID |
19834
|
| Author |
Ishida K, Nakagawa H, Murakami M.
|
| Title |
Microcyclamide, a cytotoxic cyclic hexapeptide from the cyanobacterium Microcystis aeruginosa.
|
| Journal |
J Nat Prod
|
| Abstract |
Microcyclamide (1), a cytotoxic cyclic hexapeptide, was isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-298). Its structure was elucidated to be 1 on the basis of two-dimensional (1)H-(1)H, (1)H-(13)C, and (1)H-(15)N NMR correlation experiments and the HRFABMS measurement. The absolute stereochemistry of the asymmetric centers was determined by the Marfey's method. This peptide showed a moderate cytotoxicity against P388 murine leukemia cells.
|
| Volume |
63(9)
|
| Pages |
1315-7
|
| Published |
2000-9-1
|
| DOI |
10.1021/np000159p
|
| PII |
np000159p
|
| PMID |
11000050
|
| MeSH |
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Mice
Microcystis / chemistry*
Oligopeptides / chemistry
Oligopeptides / isolation & purification*
Oligopeptides / pharmacology
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Protein Conformation
Spectrum Analysis
Tumor Cells, Cultured
|
| IF |
3.782
|
| Times Cited |
57
|
|
WOS Category
|
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
|
| Resource |
| Algae |
NIES-298 |
