RRC ID 19841
Author Itou Y, Suzuki S, Ishida K, Murakami M.
Title Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595).
Journal Bioorg. Med. Chem. Lett.
Abstract Anahaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 microg/mL, respectively.
Volume 9(9)
Pages 1243-6
Published 1999-5-3
PII S0960894X99001912
PMID 10340607
MeSH Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Peptides, Cyclic / chemistry*
IF 2.442
Times Cited 51
WOS Category CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL
Resource
Algae NIES-595