論文 - 詳細
RRC ID | 19841 |
---|---|
著者 | Itou Y, Suzuki S, Ishida K, Murakami M. |
タイトル | Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595). |
ジャーナル | Bioorg Med Chem Lett |
Abstract |
Anahaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 microg/mL, respectively. |
巻・号 | 9(9) |
ページ | 1243-6 |
公開日 | 1999-5-3 |
DOI | 10.1016/s0960-894x(99)00191-2 |
PII | S0960894X99001912 |
PMID | 10340607 |
MeSH | Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Peptides, Cyclic / chemistry* |
IF | 2.572 |
引用数 | 63 |
WOS 分野 | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL |
リソース情報 | |
藻類 | NIES-595 |