Reference - Detail
|Author||Itou Y, Suzuki S, Ishida K, Murakami M.|
|Title||Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595).|
|Journal||Bioorg. Med. Chem. Lett.|
Anahaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 microg/mL, respectively.
|MeSH||Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Peptides, Cyclic / chemistry*|
|WOS Category||CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL|