論文 - 詳細
| RRC ID | 19841 |
|---|---|
| 著者 | Itou Y, Suzuki S, Ishida K, Murakami M. |
| タイトル | Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595). |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Anahaenopeptins G (1) and H (2) were isolated from the cultured cyanobacterium Oscillatoria agardhii (NIES-595) as potent carboxypeptidase A (CPA) inhibitors. The gross structure of 1 and 2 were established by spectroscopic analysis including the 2D NMR technique and the absolute configurations of 1 and 2 were determined by the spectral and chemical methods. 1 and 2 inhibited CPA with IC50's of 0.0018 and 3.4 microg/mL, respectively. |
| 巻・号 | 9(9) |
| ページ | 1243-6 |
| 公開日 | 1999-5-3 |
| DOI | 10.1016/s0960-894x(99)00191-2 |
| PII | S0960894X99001912 |
| PMID | 10340607 |
| MeSH | Carboxypeptidases / antagonists & inhibitors* Carboxypeptidases A Cyanobacteria / chemistry* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Peptides, Cyclic / chemistry* |
| IF | 2.572 |
| 引用数 | 63 |
| WOS 分野 | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL |
| リソース情報 | |
| 藻類 | NIES-595 |