Author Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
Title Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Journal Blood
Abstract The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms.
Volume 100(1)
Pages 238-45
Published 2002-7-1
PMID 12070033
MeSH Animals Hematologic Neoplasms / classification* Hematologic Neoplasms / pathology Humans Leukemia / classification Leukemia / pathology Mice* Myeloproliferative Disorders / classification Myeloproliferative Disorders / pathology National Institutes of Health (U.S.) Neural Tube Defects / classification Neural Tube Defects / pathology Sarcoma / classification Sarcoma / pathology United States
IF 16.601
Times Cited 267
Mice SL/Kh