Reference - Detail
|Author||Yamaki H, Sitachitta N, Sano T, Kaya K.|
|Title||Two new chymotrypsin inhibitors isolated from the Cyanobacterium Microcystis aeruginosa NIES-88.|
|Journal||J. Nat. Prod.|
Micropeptins 88-N (1) and 88-Y (2), new 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptides, were isolated from Microcystis aeruginosa NIES-88. The structures were elucidated by analyses of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. Micropeptins 88-N and 88-Y inhibited chymotrypsin. The inhibitory activities were closely related to the amino acid residue that was attached to the amino group of Ahp.
|MeSH||Amino Acids / chemistry* Chymotrypsin / antagonists & inhibitors* Depsipeptides / chemistry Depsipeptides / isolation & purification* Depsipeptides / pharmacology Japan Microcystis / chemistry* Molecular Structure Nuclear Magnetic Resonance, Biomolecular Protease Inhibitors / chemistry Protease Inhibitors / isolation & purification* Protease Inhibitors / pharmacology|
|WOS Category||PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL PLANT SCIENCES|