論文 - 詳細
| RRC ID | 20268 |
|---|---|
| 著者 | Yamaki H, Sitachitta N, Sano T, Kaya K. |
| タイトル | Two new chymotrypsin inhibitors isolated from the Cyanobacterium Microcystis aeruginosa NIES-88. |
| ジャーナル | J Nat Prod |
| Abstract |
Micropeptins 88-N (1) and 88-Y (2), new 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptides, were isolated from Microcystis aeruginosa NIES-88. The structures were elucidated by analyses of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. Micropeptins 88-N and 88-Y inhibited chymotrypsin. The inhibitory activities were closely related to the amino acid residue that was attached to the amino group of Ahp. |
| 巻・号 | 68(1) |
| ページ | 14-8 |
| 公開日 | 2005-1-1 |
| DOI | 10.1021/np0401361 |
| PMID | 15679310 |
| MeSH | Amino Acids / chemistry* Chymotrypsin / antagonists & inhibitors* Depsipeptides / chemistry Depsipeptides / isolation & purification* Depsipeptides / pharmacology Japan Microcystis / chemistry* Molecular Structure Nuclear Magnetic Resonance, Biomolecular Protease Inhibitors / chemistry Protease Inhibitors / isolation & purification* Protease Inhibitors / pharmacology |
| IF | 3.782 |
| 引用数 | 39 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL PLANT SCIENCES |
| リソース情報 | |
| 藻類 | NIES-88 |