| RRC ID |
2069
|
| Author |
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.
|
| Title |
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.
|
| Journal |
Hepatol Res
|
| Abstract |
Anemia of chronic disease (ACD) is commonly observed in chronic inflammation, although its pathogenesis is poorly understood. Hepcidin is thought to be a key regulator in iron metabolism and has been implicated in ACD. Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed, it is still controversial whether interleukin-1beta (IL-1beta), also known as an inflammatory cytokine, regulates hepcidin expression. We demonstrated that hepcidin mRNA was upregulated by IL-1beta in human hepatoma-derived HuH-7 cells, particularly at low concentrations of IL-1beta, while high concentrations of IL-6 were needed for the upregulation of hepcidin mRNA. Therefore, IL-1beta might be more important for the upregulation of hepcidin in physiological conditions than IL-6. Although IL-1beta induces IL-6 production in hepatocytes, our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6. In conclusion, IL-1beta might have an important role in ACD.
|
| Volume |
33(3)
|
| Pages |
198-205
|
| Published |
2005-11-1
|
| DOI |
10.1016/j.hepres.2005.08.005
|
| PII |
S1386-6346(05)00253-6
|
| PMID |
16198622
|
| IF |
3.165
|
| Times Cited |
32
|
|
WOS Category
|
GASTROENTEROLOGY & HEPATOLOGY
|
| Resource |
| Human and Animal Cells |
HuH-7(RCB1366)
Hep G2(RCB0459)
CACO-2(RCB0988)
U-937 DE-4(RCB0435)
THP-1(RCB1189) |
