論文 - 詳細
| RRC ID | 2072 |
|---|---|
| 著者 | Nakamura K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K, Kunitomo M. |
| タイトル | Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. |
| ジャーナル | Anticancer Res |
| Abstract |
An attempt was made to elucidate the molecular targetfor the antitumor effects of cordycepin (3'-deoxyadenosine) using non-selective and selective adenosine A1, A2a, A2b and A3 receptor agonists and antagonists. Although adenosine and 2'-deoxyadenosine (up to 100 microM) had no effect, cordycepin showed remarkable inhibitory effects on the growth curves of B16-BL6 mouse melanoma (IC50= 39 microM) and mouse Lewis lung carcinoma (IC50 = 48 microM) cell lines in vitro. Among the adenosine receptor agonists and antagonists used (up to 100 microM), only 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), a selective adenosine A3 receptor agonist, notably inhibited the growth of both mouse tumor cell lines (B16-BL6; IC50 = 5 microM, LLC; 14 microM). In addition, the tumor growth inhibitory effect of cordycepin was antagonized by 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS1191), a selective adenosine A3 receptor antagonist. These results suggest that cordycepin exerts inhibitory effects on the growth of mouse melanoma and lung carcinoma cells by stimulating adenosine A3 receptors on tumor cells. |
| 巻・号 | 26(1A) |
| ページ | 43-7 |
| 公開日 | 2006-1-1 |
| PMID | 16475677 |
| MeSH | Adenosine / analogs & derivatives Adenosine / pharmacology Adenosine A3 Receptor Agonists* Adenosine A3 Receptor Antagonists Animals Antineoplastic Agents / pharmacology* Carcinoma, Lewis Lung / drug therapy* Carcinoma, Lewis Lung / pathology Cell Growth Processes / drug effects Cell Line, Tumor Deoxyadenosines / pharmacology* Dihydropyridines / pharmacology Drug Interactions Melanoma, Experimental / drug therapy* Melanoma, Experimental / pathology Mice Stimulation, Chemical |
| IF | 1.994 |
| 引用数 | 121 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |