RRC ID 20919
著者 Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A.
タイトル The role of osteocytes in bone resorption during orthodontic tooth movement.
ジャーナル J Dent Res
Abstract We investigated the roles of osteocytes in osteoclastic bone resorption during orthodontic tooth movement using the transgenic mice in which osteocytes can be specifically ablated. Because these transgenic mice express the receptor for diphtheria toxin on the cell surfaces of osteocytes, the injection of diphtheria toxin can ablate their osteocytes in vivo. Injection of diphtheria toxin into the transgenic mice significantly increased the number of ablated osteocytes in alveolar bone compared with that in wild-type mice with or without diphtheria toxin injection. Increased numbers of ablated osteocytes were observed from day 4 to day 12 after the injection in alveolar bones as well as in cortical bone of the tibiae. We applied the orthodontic force 4 days after the injection of diphtheria toxin, and the distance of tooth movement on day 12 was significantly smaller in transgenic mice than that in control mice. The numbers of osteoclasts and the quantity of eroded bone surface at the compression site were significantly reduced in the transgenic mice injected with diphtheria toxin than in control mice. These results provide in vivo demonstration of osteocyte involvement in osteoclastic bone resorption during orthodontic tooth movement.
巻・号 92(4)
ページ 340-5
公開日 2013-4-1
DOI 10.1177/0022034513476037
PII 0022034513476037
PMID 23358677
MeSH Alveolar Process / cytology* Alveolar Process / physiology Animals Apoptosis / physiology Bone Remodeling / physiology* Bone Resorption / pathology* Cell Communication Male Mice Mice, Inbred C57BL Mice, Transgenic Osteoclasts / physiology* Osteocytes / pathology Osteocytes / physiology* Stress, Mechanical Tooth Movement Techniques*
IF 4.914
引用数 35
WOS 分野 DENTISTRY, ORAL SURGERY & MEDICINE
リソース情報
実験動物マウス RBRC02237