RRC ID 20931
著者 Kimura T, Shinya M, Naruse K.
タイトル Genetic analysis of vertebral regionalization and number in medaka (Oryzias latipes) inbred lines.
ジャーナル G3 (Bethesda)
Abstract Vertebral number is the most variable trait among vertebrates. In addition to the vertebral number, the ratio of abdominal to caudal vertebrae is a variable trait. The vertebral number and the ratio of abdominal to caudal vertebrae contribute to vertebrate diversity. It is very interesting to know how to determine the vertebral number and the ratio of abdominal to caudal vertebrae. In this study, we identify differences in the vertebral number and the ratio of abdominal vertebrae to vertebral number between two inbred lines of medaka, namely, Hd-rRII1 and Kaga. To identify the genetic factor of those differences, we performed quantitative trait locus (QTL) analysis for vertebral number and the ratio of abdominal vertebrae to vertebral number using 200 F(2) fish. Our results show a suggestive QTL of the ratio of abdominal vertebrae to vertebral number on chromosome 15, and five QTL of vertebral number on chromosomes 1, 10, 11, 17, and 23. The QTL on chromosome 15 contains hoxDb cluster genes. The QTL of vertebral number include some genes related to the segmentation clock and axial elongation. In addition, we show that the difference in vertebral number between two inbred lines is derived from differences in the anteroposterior length of somites. Our results emphasize that the developmental process should be considered in genetic analyses for vertebral number.
巻・号 2(11)
ページ 1317-23
公開日 2012-11-1
DOI 10.1534/g3.112.003236
PII GGG_003236
PMID 23173083
PMC PMC3484662
MeSH Animals Animals, Inbred Strains Chromosomes / genetics Genetic Linkage Genetic Markers Homeodomain Proteins / genetics Multigene Family Oryzias / anatomy & histology Oryzias / genetics* Quantitative Trait Loci* Spine / anatomy & histology*
IF 2.781
引用数 10
WOS 分野 GENETICS & HEREDITY
リソース情報
メダカ HdrR-II1 (IB178) Kaga (IB833)